Chelsea manager Frank Lampard was delighted with the discipline of his team, who ended United's 19-game unbeaten run.
Some of England's leading players will go head-to-head from their living rooms over Easter as part of a new FIFA 20 tournament launched by the FA on Thursday.
City boss Pep Guardiola was named Manager of the Season for a third time.
Manchester City face Chelsea in the Champions League final on Saturday. Here are five key tactical battles to watch out for:
Chelsea lost their opening Premier League game with Lampard in charge 4-0 to Manchester United on Sunday and face Liverpool in the UEFA Super Cup on Wednesday.
A summary of Saturday's action in the Premier League.
Manchester City have now won only once in 11 games in all competitions.
Iran are second on three points with Wales bottom on one point and all outcomes are still possible going into the final round of games when England take on the Welsh.
England will head to the World Cup on the back of a six-match winless sequence but with at least some pride and confidence restored after a thrilling 3-3 draw at home to Germany in the Nations League on Monday.
Now, if he can keep at bay an England attack that might include club mates Raheem Sterling and Mason Mount, Mendy could yet finish the year on another high note, having started it with success in the Africa Cup of Nations.
English hopes of a run deep into the World Cup took a bit of a bruising on Friday when a lively and high-pressing United States team reduced the youthful stars of their tournament opener to anonymity.
England's Chilwell, Mount in isolation after contact with Gilmour
First-half goals by Romelu Lukaku and Hakim Ziyech knocked the stuffing out of second-tier Middlesbrough, who had eliminated Manchester United and Tottenham Hotspur in previous rounds.
Chelsea will look to make amends after being runners-up to Leicester City and Arsenal in the last two seasons
Real Madrid saw off a stirring Chelsea fightback to book their place in the Champions League semi-finals following a 3-2 defeat after extra time in a scintillating second leg at the Santiago Bernabeu on Tuesday to go through 5-4 on aggregate.
Liverpool's bandwagon rolled on as they crushed Merseyside rivals Everton 5-2
Chelsea won their second Champions League title and denied Pep Guardiola's Manchester City their first with Kai Havertz grabbing a first-half goal to secure a 1-0 win in Saturday's all-English final at the Estadio Do Dragao in Porto.
West Bromwich Albion secured a stunning 5-2 win over 10-man Chelsea at Stamford Bridge
Chelsea's Joao Felix endured a nightmare debut when he was sent off in a 2-1 Premier League defeat at local rivals Fulham.
England head into Euro 2020 with a new factor for manager Gareth Southgate to deal with -- high expectations.
Ronaldo's 62nd minute strike was his 17th league goal this season
Chelsea, Manchester City and Manchester United enjoyed comfortable wins in the English Premier League on Saturday as fans returned to stadiums after an eight-month absence.
IMAGES from the English Premier League matches played on Sunday.
Thirteen-times European champions Real, who had come through each of their last three Champions League semi-final ties, had been second best for much last week's first leg which ended 1-1.
Images from Tuesday's action in the English Premier League
Jorginho's first-half penalty earned Chelsea a 1-0 victory over Tottenham Hotspur in the Premier League on Thursday.
Tottenham were booed off at the final whistle as defeat left them in fifth place
Liverpool's Trent Alexander-Arnold scored with a spectacular strike as they overcame the loss of three players to suspected positive COVID-19 tests and conceding an early goal to beat Newcastle United 3-1 in the Premier League on Thursday.
Vibrant Chelsea made it a torrid few days for Liverpool as goals by Willian and Ross Barkley sealed a 2-0 victory to send them through to the FA Cup quarter-finals on Tuesday. Liverpool's 44-match unbeaten streak in the Premier League ended in stunning fashion with a 3-0 defeat at Watford on Saturday and they were rocked again at Stamford Bridge.
Harry Kane headed in a last-gasp equaliser to earn Tottenham Hotspur a barely-deserved 2-2 draw in a feisty Premier League derby at Chelsea that ended with both managers being shown red cards after the final whistle on Sunday.
Chelsea paid a heavy price for a 3-2 defeat at West Ham United as first Liverpool, then Manchester City, leapfrogged them in the English Premier League title race on Saturday, with City ending the day on top for the first time this season.
IMAGES from the English Premier League match played between Arsenal and Chelsea at Emirates Stadium in London on Sunday.
Daniel Ceballos fired Arsenal into the FA Cup semi-finals with a stoppage-time goal that sealed a 2-1 win over Sheffield United
Images from the Nations League matches played on Tuesday.
Despite going down to the fastest goal scored in Euro history in front of a packed Wembley stadium, the Italians held their nerve and worked their way back gradually into the game.
"It feels like a missed chance because I felt the performances were really good and the focus and the hunger was good every single day," said England midfielder Jordan Henderson.
If this sporting clash was, as English essayist, novelist and journalist George Orwell said, "war minus the shooting" both sets of players were more than ready, and set about each other with little restraint.
In a thriller at Anfield, a weakened Liverpool side came back from the brink to beat Leicester City on penalties after a 3-3 draw, setting up a semi-final against Arsenal.
Citadel proves unworthy of Priyanka's splendour, Madden's intensity or veteran talents like Lesley Manville and Stanley Tucci squandered in banal parts, complains Sukanya Verma.
Liverpool held their nerve to win an astonishing penalty shoot-out 11-10 and edge out Chelsea in the English League Cup final on Sunday after a rip-roaring contest had somehow ended 0-0 after extra time at Wembley.
